Exosomes play a vital role in the rejuvenation of all the cells in our body, so they are perfect for orthopedic issues and anti-aging.
Exosome therapy is one of the hottest areas of regenerative medicine treatment right now. Let’s dive into the essence of this treatment method in detail.
What are exosomes?
Exosomes are how cells communicate. Exosomes are a way for one cell to ‘email’ another. The message may be how to behave or what’s happening in the local area or it can even be something like a computer virus that hijacks the other cell (mRNA).
What is regenerative medicine and how is it different from other drugs?
Regenerative medicine is different from typical drugs – and potentially much more powerful.
Many drugs treat the symptoms of a problem, not the underlying cause. Erectile dysfunction after pelvic surgery, such as for prostate or colorectal cancer, appears to be caused by increased cell death (apoptosis) of corpus cavernosum smooth muscle cells (CCSMCs). This damage has been seen as always irreversible. Regenerative medicine would seek to reverse erectile dysfunction by replenishing the population of CCSMCs.
So regenerative medicine seeks to harness the body’s own regenerative capacity to heal the underlying causes of medical and other problems.
In erectile dysfunction (ED), researchers reported in 2019 that exosomes purified from mesenchymal stem cells treat ED in rats by inhibiting apoptosis in corpus cavernosum smooth muscle cells. A further report from the same research group showed that exosomes from human stem cells successfully treated ED in a diabetic rat model.
Do exosomes have something to do with stem cells?
All of the cells in your body can email each other through exosomes and this includes stem cells. The excitement behind exosomes and stem cells comes from early research showing that the positive effects of stem cells on tissue repair could also be sometimes replicated if you just used the media in which the cells were growing and got rid of the cells.
This happened through the cytokines (chemical messenger molecules) in the media as well as exosomes. Hence, the idea began that it is possible to help patients heal without stem cells, but by using only the exosomes that the stem cells produce.
How are exosomes made?
Exosomes are commonly made by growing stem cells in a culture and then taking the media (liquid) in which they grow and then getting rid of the stem cells. The media is then ultra-centrifuged since the exosomes are small. This can concentrate on the exosomes.
What is exosome therapy?
The most common uses of exosomes currently are to treat orthopedic injuries and for anti-aging. The exosomes are usually injected into the area in need of treatment, like the knee, or given intravenously for anti-aging. The idea is that they will promote tissue repair.
How do exosomes work?
Exosomes carry genetic information. Protein and messenger RNA can relay this information, letting cells know when to and how to react. This exosome cell-to-cell communication is possible due to its unique shape and content.
Exosomes from young stem cells rejuvenate the older cells and assist in calming an overactive immune system or modulating it to respond in a coordinated and more effective fashion.
What is exosome therapy used for?
Hair Loss. Exosome injection can be used to regrow hair loss due to its growth factor content. When injected, the exosome will trigger healing, cell stimulation, and natural regeneration of these hair follicles.
Exosomes are ideal for people with thinning hair, excessive shedding, or hair loss proper. This is because exosomes are regenerative cells that can heal, repair, stimulate, and restore cells and tissues.
Lyme Disease. Exosomes may help to regulate processes in the body, and may also be beneficial to patients with Lyme disease. Lyme disease is a very complex disorder that compromises the immune system.
Many Lyme patients suffer from dysfunction of the mast cells, increasing their inflammatory response and metabolic function. Incorporating exosomes treatment in their treatment regimen will help break the inflammatory response and provide the body with necessary cellular information to facilitate healing.
Arthritis. Arthritis is the joint inflammation resulting from an autoimmune disease. Although various types of treatment are available to alleviate symptoms, no known therapy has been confirmed effective in reversing the disease progression.
In the field of regenerative medicine today, with the discovery of extracellular microvesicles, especially exosomes, many researchers have been able to offer a more exciting alternative on this subject matter. Exosome arthritis therapy is believed to play a more substantial role in bone and cartilage remodeling.
In a nutshell, exosomes provide enormous potential in the field of regenerative medicine. In our turn, we are here for you to offer the best possible treatment methods for the illnesses you are tired to fight.
Are exosomes safe?
Biologists have utilized exosomes as a diagnostic and preventative tool for decades. When produced in Mesenchymal Stem Cells (MSCs), they’ve been shown to help reduce inflammation, the root cause of many autoimmune dysfunctions. They’ve also been clinically proven to help grow new blood vessels (angiogenesis) more efficiently than whole stem cells.
One of the most common causes of ED is diabetes, which can damage the blood supply to the penis and the nerves that control an erection. A study published in The Journal of Sexual Medicine last year demonstrated that stem cell-derived exosomes alleviate diabetic erectile dysfunction.
Another 2018 study demonstrated that erectile function caused by cavernous nerve injury (CNI) was significantly improved with MSC exosome treatment. It enhanced smooth muscle and collagen content while preventing cell death in the corpus cavernosum (the bulk of penis tissue).
Exosomes from stem cells are an emerging regenerative medicine that could disrupt the way age-related degeneration is treated, including problems such as cardiovascular disease, neurodegeneration, osteoporosis, and erectile dysfunction.
Exosome products do not contain stem cells, and therefore, do not contain genetic material (DNA) from someone else potentially reducing risks of side effects. As with any injection therapy, there is always a risk of bruising, swelling, infection, or discomfort. The side effects are often temporary and typically last less than 24 hours but may last up to three days.
If you are about to start the therapy and got some additional questions, feel free to contact our team of professionals here.